No association between the GSTM1 and GSTT1 polymorphism and endometrial cancer risk: A meta-analysi

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No association between the GSTM1 and GSTT1 polymorphism and endometrial cancer risk: A meta-analysi

Purpose: A number of case-control studies have been conducted to investigate the association of glutathione S-transferase (GST) genetic polymorphisms and endometrial carcinoma risk. However, these studies have yielded contradictory results. We therefore performed a meta-analysis to derive a more precise estimation of the association between polymorphisms on GSTM1, GSTT1 and endometrial carcinom...

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Glutathione S-transferases (GSTs; EC: 2.5.1.18) are a ubiquitous family of eukaryotic and prokaryotic phase II metabolic isozymes. Genes encoding GSTM1 (OMIM: 138350), and GSTT1 (OMIM: 600436) are members of class mu and theta, respectively. The most common polymorphism in the GSTM1 is a deletion of the whole GSTM1 gene with a lack of enzyme activity. A homozygous deletion in the GSTT1 has also...

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ژورنال

عنوان ژورنال: Open Journal of Obstetrics and Gynecology

سال: 2013

ISSN: 2160-8792,2160-8806

DOI: 10.4236/ojog.2013.34072